Natural History of Infectious Disease

Natural history of Huntington disease.

IMPORTANCE Understanding the natural history of Huntington disease will inform patients and clinicians on the disease course and researchers on the design of clinical trials. OBJECTIVE To determine the longitudinal change in clinical features among individuals with Huntington disease compared with controls. DESIGN, SETTING, AND PARTICIPANTS Prospective, longitudinal cohort study at 44 resea...

Natural history of Hartnup disease.

Hartnup disease was diagnosed in 12 children and 3 of their 15 sibs in the course of routine urine screening of 6-week-old infants in New South Wales. These children were followed for up to 8 years, during which time there were only two clinical episodes which might be ascribed to Hartnup disease. The mental development of all the children was normal. 10 had height centiles less than the midpar...

The natural history of disease

Ministry prepared dutifully to administer the service, and Britain obtained health care free at the point of delivery for all-a system which, despite exceeding all original financial estimates, became, in fact, the most cost-efficient in the world. Bevan realised a socialist dream, but Honigsbaum claims that the real ideological roots of National Health provision were the Christian principles o...

[Charles Nicolle's theory on the natural history of infectious diseases].

Natural history of severe thrombocytopenia in infectious mononucleosis.

The natural history of severe thrombocytopenia in two patients with infectious mononucleosis (minimum platelet counts under 10 x 109 and 17 x 109/1 respectively) is described. In both, the platelet count rose rapidly and spontaneously, reaching approximately 100 x 109l/l on the seventh day. Bleeding symptoms were also transient and never life-threatening. The possibility of very rapid spontaneo...